Novel biomaterials for Tissue Engineering
Scaffold based on coral-derived collagen fibers
In collaboration with Prof. Rami Haj-Ali (TAU, Mechanical Engineering), we extract centimeter-long collagen fibers from Sarcophyton soft corals, and wrap them around frames to create aligned fiber arrays. We study their biocompatibility and ability to support formation of various oriented tissues, such as skeletal muscle tissue.
- Ortal Shelah, Shir Wertheimer, Rami Haj-Ali, Ayelet Lesman. Coral-derived Collagen Fibers for Engineering Aligned Tissues. Tissue Engineering Part A. July 2020, 27, 3-4. Feb 15, 2021. http://doi.org/10.1089/ten.tea.2020.0116
- Shir Wertheimer, Mirit Sharabi, Ortal Shelah, Ayelet Lesman, Rami Haj-Ali. Bio-composites reinforced with unique coral collagen fibers: Towards biomimetic-based small diameter vascular grafts. Journal of the Mechanical Behavior of Biomedical Materials, April 2020, In Press.
Seaweed cellulose scaffolds from green macroalgae
In collaboration with Prof. Alexander Golberg (Porter environment, TAU), we apply decellularization-recellularization approach of Marine macroalgae species Ulva sp. and Cladophora sp. to produce cellulose scaffolds for in-vitro mammalian cell growth. We test their biocompatibility and ability to support tissue engineering.
Nurit Bar-Shai, Orna Sharabani-Yosef, Meiron Zollmann, Ayelet Lesman, Alexander Golberg. Seaweed cellulose scaffolds derived from green macroalgae for tissue engineering. Scientific Reports. 2021 Jun 4;11(1):11843. doi: 10.1038/s41598-021-90903-2. PMID: 34088909.